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FLASH GENE
Symbol TP53I3 contributors: mct - updated : 10-10-2012
HGNC name tumor protein p53 inducible protein 3
HGNC id 19373
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
zinc binding dehydrogenase domain
HOMOLOGY
intraspecies homolog to quinone oxidoreductase
Homologene
FAMILY medium chain dehydrogenase/reductase superfamily
CATEGORY regulatory
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • involved in TP53-mediated cell death
  • its action is through oxidative stress produced by its enzymatic activity and provides essential knowledge for eventual control of apoptosis
  • role in the activation of DNA damage checkpoints, after UV irradiation or radiomimetic drug neocarzinostatin (NCS)
  • critical component of the DNA damage response pathway, having a direct role in the transmission of the DNA damage signal from damaged DNA to the intra-S and G2/M checkpoint machinery in human cells
  • may possibly have a role in cancer cell survival
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • a novel signaling pathway of GPX3-TP53I3 in the regulation of cell death in prostate cancer
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • contributes to the recruitment of TP53BP1, MRE11A, RAD50 and NBS1 to the sites of DNA break lesions in response to DNA damage
    • cell & other
    REGULATION
    induced by Tp53
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to cancer
    Variant & Polymorphism repeat microsatellite affecting an individual susceptibility to cancer
    Candidate gene
    Marker TP53I3 and SPSB2 might have the potential to serve as non-invasive markers of oocyte aneuploidy
    Therapy target
    ANIMAL & CELL MODELS