Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

TP53I3

contributors: mct - updated : 10-10-2012

HGNC name	tumor protein p53 inducible protein 3
HGNC id	19373

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2p24.1      Physical location : 24.300.304 - 24.307.728
Genatlas name	P53-induced gene 3
Synonym name	quinone oxidoreductase homolog
Synonym symbol(s)	PIG3

DNA

TYPE	functioning gene
STRUCTURE	7.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif	repetitive sequence
text structure	motif (TGYCC)15 microsatellite in the promoter is the first tp53 responsive element shown to be polymorphic

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004881 5 - 2042 NP_004872 - 332 - 2002 11919562 NM_147184 6 - 1643 NP_671713 - 332 - 2002 11919562 NM_001206802 4 - 961 NP_001193731 - 248 - 2002 11919562 PIG3ex4 - splicing - - - - 2008 18801469 modulated in response to UV radiation numerous factors contribute to the normal alternative splicing of PIG3ex4 and UV-inducible increases in this process require that the splicing of this exon be maintained in a sufficiently weakened state under normal conditions

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain hindbrain medulla oblongata

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone subchondral     Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

eye

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

zinc binding dehydrogenase domain

HOMOLOGY

intraspecies

homolog to quinone oxidoreductase

Homologene

FAMILY

medium chain dehydrogenase/reductase superfamily

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

basic FUNCTION	involved in TP53-mediated cell death
	its action is through oxidative stress produced by its enzymatic activity and provides essential knowledge for eventual control of apoptosis
	role in the activation of DNA damage checkpoints, after UV irradiation or radiomimetic drug neocarzinostatin (NCS)
	critical component of the DNA damage response pathway, having a direct role in the transmission of the DNA damage signal from damaged DNA to the intra-S and G2/M checkpoint machinery in human cells
	may possibly have a role in cancer cell survival

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a novel signaling pathway of GPX3-TP53I3 in the regulation of cell death in prostate cancer

a component

INTERACTION

DNA

RNA

small molecule

protein

contributes to the recruitment of TP53BP1, MRE11A, RAD50 and NBS1 to the sites of DNA break lesions in response to DNA damage

cell & other

REGULATION

induced by

Tp53

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to cancer

Variant & Polymorphism repeat	microsatellite affecting an individual susceptibility to cancer

Candidate gene
Marker	TP53I3 and SPSB2 might have the potential to serve as non-invasive markers of oocyte aneuploidy
Therapy target

ANIMAL & CELL MODELS