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FLASH GENE

Symbol

OLIG2

contributors: shn/mct - updated : 30-01-2024

HGNC name	oligodendrocyte lineage transcription factor 2
HGNC id	9398

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	in Olig1(-/-)2(-/-) double-mutant mice motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished
	mice lacking Olig2 function demonstrates a failure of NG2 cell development at embryonic and perinatal stages
	in Olig2 deficient mouse, astrocyte development was retarded in the dorsal neocortex, but not in the basal forebrain
	Olig2 is triplicated and overexpressed in the Ts65Dn mouse (mouse models of Down syndrome) forebrain displaying cognitive deficits