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FLASH GENE

Symbol

OLIG2

contributors: shn/mct - updated : 30-01-2024

HGNC name	oligodendrocyte lineage transcription factor 2
HGNC id	9398

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function activated in T cell lymphoblastic leukemia with t(14;21) (q11.2;q22) constitutional     --over   acute and chronic brain injury tumoral     --low   may be related to the malignant behavior of human glioblastoma tumoral     --over   in oligodendroglial tumors constitutional   amplification     Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome constitutional     --over   over-expression inhibits neural progenitor proliferation through changes in potassium channel activity, thereby contributing to the reduced neuronal numbers and brain size in Down syndrome constitutional   deletion     in the cerebellum, deletion of both OLIG2 and OLIG1 results in impaired genesis of Purkinje cells (PCs) and Pax2(+) interneurons tumoral     --over   in diffuse intrinsic pontine glioma (DIPG)

Susceptibility

to schizophrenia

Variant & Polymorphism SNP	SNP rs762178 in OLIG2 seems to be a potential candidate in altering risk for schizophrenia in the Chinese Han population

Candidate gene
Marker	a molecular marker for human glial brain tumors
	a marker for the diagnosis of oligodendroglial tumours
Therapy target
	System Type Disorder Pubmed cancer brain   likely target gene as novel candidates in diffuse intrinsic pontine glioma (DIPG) therapy

ANIMAL & CELL MODELS

	in Olig1(-/-)2(-/-) double-mutant mice motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished
	mice lacking Olig2 function demonstrates a failure of NG2 cell development at embryonic and perinatal stages
	in Olig2 deficient mouse, astrocyte development was retarded in the dorsal neocortex, but not in the basal forebrain
	Olig2 is triplicated and overexpressed in the Ts65Dn mouse (mouse models of Down syndrome) forebrain displaying cognitive deficits