basic FUNCTION
| plays in cooperation with Neurogenin2 vital roles in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons |
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required for oligodendrocytes and motor neuron specification in the spinal cord |
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controlling the development of neural crest cells, astrocytes and oligodendrocytes, three neuroectodermal-derived cells |
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plays critical roles in oligodendrocyte and motor neuron development |
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export of OLIG2, stimulated AKT, by from the nucleus of neural stem cell is essential for the astrocyte differentiation |
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required for the production of motor neurons and oligodendrocytes |
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repressor of neurogenesis in cells reacting to brain injury and open innovative perspectives toward evoking endogenous neuronal repair |
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having repressor function, both sufficient and necessary to prevent neuronal differentiation and to direct subventricular zone progenitors toward astrocytic and oligodendrocytic fates |
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required for proliferation of neural progenitors and for glioma formation |
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playing a crucial role in white matter astrocyte development, but not in the cortical gray matter astrocytes |
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role in gliogenesis in the dorsal pallium |
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play a role in ventral telencephalic neurogenesis |
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marks a subpopulation of retinal progenitor cells (RPCs) that are biased toward the production of postmitotic progeny |
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required for oligodendrocyte specification and differentiation |
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has the ability to permeate the cell membrane without the addition of a protein transduction domain (PTD), similar to other basic helix-loop-helix transcription factors such as MYOD1 and NEUROD2 |
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OLIG2 itself had a transduction ability similar to other bHLH transcription factors |
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functions as a prepatterning factor to direct SMARCA4 to oligodendrocyte-specific enhancers |
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basic helix-loop-helix transcription factor necessary for oligodendroglial development and expressed continuously throughout the lineage |
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is involved in correct formation of the prethalamus, which leads to exclusion of the EPHA3-expressing region and is crucial for proper thalamocortical axons (TCAs) formation |
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plays a pivotal role in glioma development |
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plays a crucial role in the neurogenesis of both spinal cord and brain |
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OLIG2 is an onco-requisite factor in diffuse intrinsic pontine glioma (DIPG) |
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OLIG2-lineage astrocytes are likely involved in inhibitory neuronal transmission |
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novel function of OLIG2 in the periphery nervous system to regulate the terminal differentiation and maturation of olfactory sensory neurons |
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is an important transcription factor essential for the specification and differentiation of oligodendrocytes as well as astrocytes and neurons during developmental stages |
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functional roles of OLIG1 and OLIG2 in directing neuronal and glial formation during different stages in development |
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is a transcription factor that activates the expression of myelin-associated genes in the oligodendrocyte-lineage cells |
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OLIG2 is likely essential for anterior commissure formation, likely by regulating multiple biological processes |