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FLASH GENE
Symbol TLX3 contributors: mct/npt - updated : 21-02-2017
HGNC name T-cell leukemia homeobox 3
HGNC id 13532
DNA
TYPE functioning gene
STRUCTURE 2.85 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1513 31.9 291 - Nagel (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • homeobox domain
    • HOMOLOGY
    interspecies homolog to murine respiratory neuron homeobox
    intraspecies homolog to HOX 11
    Homologene
    FAMILY
  • homeodomain family of DNA binding protein
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the development of the ventral medullary respiratory center
  • able to first induce a set of proneural genes, followed by activation of neural subtype-specific genes
  • exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells
  • functions as the master neuronal fate regulator by instructively promoting the specification of glutamatergic excitatory neurons and suppressing the specification of gamma-aminobutyric acid (GABAergic) neurons
  • promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CREBBP
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS respiration
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TLX3 directly interacts with the epigenetic co-activator cyclic adenosine monophosphate CREBBP and its homeodomain is essential for this interaction
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TALL
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with BCL11B, in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia
    tumoral fusion      
    with CDK6 in t(5;7)(q35;q21), and RANBP17 in T-ALL
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS