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FLASH GENE
Symbol POU6F2 contributors: mlc - updated : 14-11-2007
HGNC name POU class 6 homeobox 2
HGNC id 21694
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one homeobox DNA-binding domain
  • a bipartite DNA-binding domain, consisting of a POU-specific domain and a POU heterodomain, separated by a variable polylinker
    • HOMOLOGY
    Homologene
    FAMILY
  • POU homeodomain family of transcription factors
  • class- 6 subfamily
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • tumor suppressor involved in hereditary predisposition to Wilms tumor
  • involved in early steps in the differentiation of amacrine and ganglion cells
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development , nervous system
    text central nervous system development
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in Wilms tumor
    tumoral germinal mutation      
    in Wilms tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS