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FLASH GENE
Symbol IL19 contributors: mct - updated : 09-03-2015
HGNC name interleukin 19
HGNC id 5990
Location 1q32.2      Physical location : 206.972.214 - 207.016.324
Synonym name
  • melanoma differentiation associated protein-like protein
  • Synonym symbol(s) MDA1,IL-19,IL10C,ZMDA1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text IL 10 family cluster (with IL 10, IL 20 and IL24)
    STRUCTURE 44.11 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   HRE
    text structure
  • a regulatory region (PE), 148bp upstream of exon 1 of IL19
  • IL4 increases the binding of STAT6 to its response elements in the IL19 promoter
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC391156 1 LOC391156 FNBP2 1q31.3 formin binding protein 2 IKBKE 1q32.1 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon RASSF5 1q32.1 Ras association (RalGDS/AF-6) domain family 5 LGTN 1q31-q32 ligatin DYRK3 1q32 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 MAPKAPK2 1q32 mitogen-activated protein kinase-activated protein kinase 2 IL10 1q31.3-q32.1 interleukin 10 IL19 1q32.2 interleukin 19 IL20 1q32 interleukin 20 IL24 1q32 interleukin 24 TOSO 1q32.1 regulator of Fas-induced apoptosis PIGR 1q32 polymeric immunoglobulin receptor FKSG87 1q32.1 FKSG87 protein LOC387623 1 hypothetical gene supported by NM_024115 SARG 1q32.1 specifically androgen-regulated protein DKFZp451J1719 1q32.1 hypothetical DKFZp451J1719 PFKFB2 1q31 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 C4BPB 1q32 complement component 4 binding protein, beta C4BPA 1q32 complement component 4 binding protein, alpha LOC343024 1q32.1 similar to C4BP alpha chain precursor - rabbit C4BPAL2 1q32 complement component 4 binding protein, alpha-like 2 DAF 1q32 decay accelerating factor for complement (CD55, Cromer blood group system) FLJ13310 1q32.1 hypothetical protein FLJ13310 CR2 1q32 complement component (3d/Epstein Barr virus) receptor 2
    RNA
    TRANSCRIPTS type messenger
    text at least two distinct mRNA differing in their 5 prime sequences
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1048 - 215 - 2006 16631120
    containing an alternative inititing ATG codon that is in frame with the rest of the coding sequence
    7 - 1848 - 177 - 2006 16631120
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a signal peptide,two potential N-linked glycosylation sites and four conserved cysteine residues necessary for correct folding of the IL 10 monomer
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to IL10
    Homologene
    FAMILY IL10 family of cytokines
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • playing a role in down regulatory antigen presentation and macrophage activation
  • is involved in the pathogenesis of endotoxic shock
  • is an immunomodulatory cytokine, the expression of which is reported to be restricted to inflammatory cells
  • through induction of SOCS5 and inhibition of signal transduction, IL19 expression in VSMCs may represent a novel, protective, autocrine response of VSMCs to inflammatory stimuli
  • is mitogenic and chemotactic for endothelial cell (EC) and can induce the angiogenic potential of ECs
  • involved in keratinocyte proliferation in psoriasis
  • decreases leukocyte-endothelial cell interactions by reduction in endothelial cell adhesion molecule mRNA stability
  • playing a role in B cell activation and autoantibody production
  • has an autocrine effect in breast cancer cells, and directly promotes proliferation and migration and indirectly provides a microenvironment for tumor progression
  • the bacterially induced production of IL19 by astrocytes, and the immunomodulatory effects of this cytokine, suggest a novel mechanism by which astrocytes can regulate CNS inflammation
  • IL24 and IL19 are involved in host defence against bacteria and fungi, tissue remodelling and wound healing
  • plays an important role in asthma by stimulating T helper type 2 (Th2) cytokine production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    text anti inflammatory properties
    PATHWAY
    metabolism
    signaling
  • molecular pathway for IL4 up-regulation of IL19 in keratinocytes, which may play an important role in atopic dermatitis (AD) pathogenesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL19 induced activation of STAT3 as well as the expression of the suppressor of cytokine signaling 5 (SOCS5) in vascular smooth muscle cells (VSMCs)
  • IL19 is important for cutaneous wound healing because it upregulates FGF7 expression
  • cell & other
    REGULATION
    induced by the presence of IL 4 or IL 13 in LPS-treatment stimulated monocytes
    granulocyte-macrophage colony stimulating factor
    LPS-treatmant in monocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to ulcerative colitis (UC)
    Variant & Polymorphism SNP
  • IL19 polymorphisms (rs2243188 and rs2243193) might have a protective role in the development of UC
  • Candidate gene
    Marker
  • is a prognostic marker in breast cancer
  • Therapy target
    ANIMAL & CELL MODELS