Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol STK11IP contributors: - updated : 20-11-2006
HGNC name serine/threonine kinase 11 interacting protein
HGNC id 19184
Location 2q35      Physical location : 220.462.595 - 220.481.172
Synonym name leucine rich repeat protein interacting with LKB1
Synonym symbol(s) LIP1, KIAA1898, LKB1IP, STK11IP1
DNA
TYPE functioning gene
STRUCTURE 18.00 kb     25 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D2S164 - D2S295 - STK11IP - D2S163 - qter
Authors Smith (02)
regionally located close to SLC4A3
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Nervousnervecranial nerve  predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six tandem leucine-rich repeats (LRR)
  • a highly glutamic region
  • a possible leucine zipper
  • HOMOLOGY
    interspecies homolog to chimpanzee STK11IP (97.1 pc)
    homolog to rattus Stk11ip (75.6 pc)
    homolog to murine Stk11ip (75.5 pc)
    intraspecies homolog to IRAS1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • colocalized with LKB1
  • basic FUNCTION
  • controlling the subcellular localization of STK11 (LKB1)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • may be involved in TGFB1 signaling
  • a component
  • forming a complex with STK11, MADH4 and LIP1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STK11
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS