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FLASH GENE
Symbol DHX34 contributors: mct - updated : 21-08-2015
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 34
HGNC id 16719
Corresponding disease
NDDRA neurodevelopmental disorder with renal anomalies
Location 19q13.32      Physical location : 47.852.537 - 47.885.961
Synonym name
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34
  • probable ATP-dependent helicase DHX34
  • Synonym symbol(s) KIAA0134, HRH1, DDX34
    EC.number 3.6.4.13
    DNA
    TYPE functioning gene
    STRUCTURE 33.42 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390946 19 similar to Serine/threonine protein phosphatase 5 (PP5) (Protein phosphatase T) (PP-T) (PPT) LOC390947 19 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) CALM3 19q13.3 calmodulin 3 (phosphorylase kinase, delta) PTGIR 19q13.3 prostaglandin I2 (prostacyclin) receptor (IP) GNG8 19q13.2-q13.3 guanine nucleotide binding protein (G protein), gamma 8 MGC15476 19q13.33 thymus expressed gene 3-like PRKD2 19q13.2 thymus expressed gene 3-like STRN4 19q13.2 striatin, calmodulin binding protein 4 FKRP 19q13.33 fukutin related protein SLC1A5 19q13.3 solute carrier family 1 (neutral amino acid transporter), member 5 LOC390948 19 similar to heterogeneous nuclear ribonucleoprotein M isoform a; heterogenous nuclear ribonucleoprotein M4; N-acetylglucosamine receptor 1; M4 protein; heterogenous nuclear ribonucleoprotein M AP2S1 19q13.2-q13.3 adaptor-related protein complex 2, sigma 1 subunit GRLF1 19q13.3 glucocorticoid receptor DNA binding factor 1 NPAS1 19q13.2-q13.3 neuronal PAS domain protein 1 FLJ20512 19q13.33 hypothetical protein FLJ20512 C19orf7 19q13.33 chromosome 19 open reading frame 7 SAE1 19q13.33 SUMO-1 activating enzyme subunit 1 BBC3 19q13.3-q13.4 BCL2 binding component 3 DKFZP586M1019 LOC255783 19q13.33 hypothetical protein LOC255783 C5R1 19q13.3-q13.4 complement component 5 receptor 1 (C5a ligand) GPR77 19q13.33 G protein-coupled receptor 77 DHX34 19q13.3 DEAH (Asp-Glu-Ala-His) box polypeptide 34 MRG2 KPTN 19q13.3 kaptin (actin binding protein) NAPA 19q13.3 N-ethylmaleimide-sensitive factor attachment protein, alpha DKFZp434I1930 GLTSCR1 19q13.3 glioma tumor suppressor candidate region gene 1 EHD2 19p13.3 EH-domain containing 2 GLTSCR2 19q13.3 glioma tumor suppressor candidate region gene 2 SEPW1 19q13.3 selenoprotein W, 1 LOC390949 19 similar to 60S ribosomal protein L23a FLJ40321 19q13.33 FLJ40321 protein CRX 19q13.3 cone-rod homeobox SULT2A1 19q13.3 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1 ELSPBP1 19q13.33 epididymal sperm binding protein 1 CABP5 19q13.3 calcium binding protein 5 PLA2G4C 19q13.3 phospholipase A2, group IVC (cytosolic, calcium-independent)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4385 128 1143 - 2011 21227923
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Nervousbrainhindbrainmedulla oblongata  
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelial    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a DEAD/H box (Asp-Glu-Ala-Asp/His)
  • C terminal RNA helicase domain
  • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DEAH subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • ATP-binding RNA helicase
  • having nucleic acid binding, helicase activities
  • acts as a scaffold required for successful NMD of aberrant mRNA transcripts
  • DHX34 and NBAS act in concert with core nonsense-mediated mRNA decay (NMD) factors to co-regulate a large number of endogenous RNA targets
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
  • ATP
  • protein
  • is recruited to the SURF complex via its preferential interaction with hypophosphorylated UPF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDDRA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS