Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
Symbol DHX8 contributors: mct - updated : 27-02-2020
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 8
HGNC id 2749
Location 17q21.31      Physical location : 41.561.333 - 41.601.680
Synonym name
  • sperm autoantigenic protein 17
  • human RNA helicase 1
  • Synonym symbol(s) PRP22, HRH1, DDX8, C6C1, Dhr2, PRPF22
    TYPE functioning gene
    STRUCTURE 60.93 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PSME3 17q21 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) AOC2 17q21 amine oxidase, copper containing 2 (retina-specific) AOC3 17q21 amine oxidase, copper containing 3 (vascular adhesion protein 1) LOC90586 17q21.31 amine oxidase pseudogene LOC388387 17 hypothetical gene supported by AK055784 G6PC 17q21 glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease) MGC2744 17q21.31 hypothetical protein MGC2744 DKFZp761H0421 17q21.31 hypothetical protein DKFZp761H0421 RPL27 17q21 ribosomal protein L27 IFI35 17q21 interferon-induced protein 35 VAT1 17q21 vesicle amine transport protein 1 homolog (T californica) ARHN 17q21 ras homolog gene family, member N BRCA1 17q21 breast cancer 1, early onset RPL21P4 17q21 ribosomal protein L21 pseudogene 4 NBR2 17q21 neighbor of BRCA1 gene 2 LOC387620 17 membrane component, chromosome 17, surface marker 2 MGC20235 17q21.31 hypothetical protein MGC20235 LOC388388 17 LOC388388 RNU2P2 17q21.31 RNA, U2 small nuclear pseudogene 2 ARF4L 17q12-q21 ADP-ribosylation factor 4-like LOC284064 17q21.31 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) DHX8 17q21.31 DEAH (Asp-Glu-Ala-His) box polypeptide 8 ETV4 17q21 ets variant gene 4 (E1A enhancer binding protein, E1AF) MEOX1 17q21 mesenchyme homeo box 1 LOC390797 17 similar to WHSC1L1 protein isoform long; Wolf-Hirschhorn syndrome candidate 1-like 1 protein SOST 17q12-q21 sclerosteosis DUSP3 17q21 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) LOC284067 17q21.31 hypothetical LOC284067 MPP3 17q12-q21 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) TREM4 17q21.31 triggering receptor expressed on myeloid cells 4 MPP2 17q12-q21 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) APR-2 17q21.31 apoptosis related protein LOC390798 17 similar to wingless-type MMTV integration site family, member 9B precursor; wingless-type MMTV integration site family, member 15 PPY 17q21.2 pancreatic polypeptide PYY 17q21.1 peptide YY NAGS 17q21.31 peptide YY MGC4251 17q21.31 hypothetical protein MGC4251 FLJ30656 17q21.31 hypothetical protein FLJ30656 G6PC3 17q21.31 glucose-6-phosphatase catalytic subunit 3 HDAC5 17q21 histone deacetylase 5
    regionally located in a region duplicated on 16p
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 4392 - 945 - 2017 28062851
    23 - 4304 - 1218 - 2017 28062851
    22 - 4224 - 1129 - 2017 28062851
    24 - 4231 - 1169 - 2017 28062851
    23 - 4111 - 1152 - 2017 28062851
    23 - 3833 - 1181 - 2017 28062851
    23 - 3827 - 1179 - 2017 28062851
    23 - 5549 - 1220 - 2017 28062851
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Cardiovascularheart   highly
    Reproductivemale systemprostate  highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    SystemCellPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
  • a N terminal DEAD/H (Asp-Glu-Ala-Asp/His) domain
  • a C terminal helicase domain
  • a nuclear localization signal (NLS)
  • a RS domain (serine rich domain)
    interspecies ortholog to yeast S.cerevisiae Prp22
    homolog to murine Ddx8
    homolog to Drosophila CG8241
    homolog to C.elegans mog-5
    FAMILY DEAD/H box family, DEAH subfamily
    CATEGORY enzyme , RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    text transport to nucleus dependent on active RNA POL II transcription
    basic FUNCTION
  • releasing of spliced mRNA from the spliceosome
  • putative RNA helicase with RNA dependent ATPase
  • is a crucial component of the eukaryotic pre-mRNA splicing machinery
  • cellular complexes comprising CACTIN, DHX8 and SRRM2 sustain precise chromosome segregation, genome stability and cell proliferation by allowing faithful splicing of specific pre-mRNAs
  • is a crucial DEAH-box RNA helicase involved in splicing and required for the release of mature mRNA from the spliceosome
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text nuclear export of spliced mRNA
    a component spliceosome complex
    RNA binding
    small molecule nucleotide,
  • SNW1-associated factors DHX8 and PRPF19 are also selectively required for CDKN1A expression under stress
  • CACTIN physically and functionally interacts with the spliceosome-associated factors DHX8 and SRRM2
  • cell & other