Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

CFD

contributors: mct - updated : 11/03/2024

HGNC name	complement factor D (adipsin)
HGNC id	2771

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   significantly decreased in patients with asymptomatic carotid atherosclerosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	adipsin is a novel biomarker that predicts all-cause death and rehospitalization in patients with coronary artery disease
	is a biomarker in Type 2 Diabetes Mellitus
	could be a reliable diagnostic biomarker involved in the pathophysiology of Barraquer-Simons syndrome by promoting unrestrained local complement system activation in the adipose tissue environment
	is likely a novel plasma biomarker to monitor the increased risk of preeclampsia in early pregnancy
	role for Adipsin as a potential marker of asymptomatic carotid atherosclerosis
Therapy target
	System Type Disorder Pubmed cardiovascular atheroma   may be a potential therapeutic target against atherosclerosis

ANIMAL & CELL MODELS

	factor D-deficient mice had no apparent abnormality in development and their body weights were similar to those of factor D-sufficient littermates
	obese mice exhibited decreased levels of adipsin in adipose tissues and serum and increased ER stress markers in adipose tissues compared to lean mice