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FLASH GENE

Symbol

NQO1

contributors: mct/npt - updated : 04-07-2023

HGNC name	NAD(P)H dehydrogenase, quinone 1
HGNC id	2874

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in tardive dyskinesia tumoral     --over   associated with breast cancer progression constitutional     --over   in the early and intermediate stages of Parkinson's disease (PD) and disappeared in the end-stage PD

Susceptibility

to benzene toxicity modifying the susceptibility to acute myeloid leukemia to various forms of cancer to breast cancer with poor survival to artery plaques in type 2 diabetic patients

Variant & Polymorphism other	Cb09T TT phenotype with no NQO1 activity (susceptible)
	allele 2 and 3 increases the risk of ALL
	an increased risk of hematotoxicity after exposure to benzene
	homozygote missense variant increasing the risk of breast cancer with poor survival
	C609T polymorphism is associated with carotid artery plaques in type 2 diabetic patients (Han 2009)

Candidate gene	prognostic and predictive marker for breast cancer
Marker	may be a potential biomarker for poor prognostic evaluation of breast cancers
Therapy target
	System Type Disorder Pubmed cancer digestive liver might be a potential therapeutic target for HCC neurology neurodegenerative Parkinson/dementia Parkinsonism blockade of AKT1-mediated NQO1 degradation may ameliorate PD pathogenesis

ANIMAL & CELL MODELS