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FLASH GENE
Symbol COLEC12 contributors: shn - updated : 18-01-2011
HGNC name collectin sub-family member 12
HGNC id 16016
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal contains a leucine zipper transmembrane region, a cytosolic and an extracellular domain
  • C type lectin
  • a coiled-coil domain
  • a collagen domain
  • C-terminal C-type lectin/carbohydrate recognition domain, that interacts with specific glycans
  • several putative sites for N-glycosylation
  • a serine/threonine-rich region
  • a putative internalization signal
  • conjugated GlycoP
    mono polymer trimer
    HOMOLOGY
    interspecies ortholog to Colec12, Mus musculus
    homolog to si:ch211-212m21.5, Danio rerio
    ortholog to COLEC12, Pan troglodytes
    ortholog to Colec12, Rattus norvegicus
    Homologene
    FAMILY
  • family of class A scavenger receptors
  • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 2 membrane protein
    basic FUNCTION
  • involved in host defenses
  • might play important roles in host defenses and/or atherosclerosis formation
  • having scavenger function as to carbohydrate-containing ligands
  • may participate in removing oxidatively damaged or apoptotic cells
  • could be the receptor involved in the binding or clearing of Abeta by glial and vascular/perivascular cells in Alzheimer disease
  • mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein
  • predominantly mediated phagocytosis for fungi in vascular endothelia
  • may be playing a role in the clearance of amyloid beta in Alzheimer disease
  • shares structural features with both collectins and type A scavenger receptors
  • plays a role in the host defense system and in the clearance of glycoproteins from the blood
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens, sialyl Lewis X or a trisaccharide and asialo-orosomucoid
  • protein
  • fibrillar beta amyloid peptide
  • zymosan
  • binds via its lectin domain to desialyated Lewis X containing glycoproteins and it is able to facilitate internalization of bound ligands
  • cell & other
  • binding to carbohydrate antigens on microorganisms
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS