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FLASH GENE
Symbol COLEC12 contributors: shn - updated : 18-01-2011
HGNC name collectin sub-family member 12
HGNC id 16016
DNA
TYPE functioning gene
STRUCTURE 181.38 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map tel - COLEC12 - D18S1140 - D18S59 - cen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 splicing 3134 81.4 742 - 2006 16868960
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
 vesselscapillary   
Digestiveintestinelarge intestinecolon moderately
 intestinesmall intestine  highly
Lymphoid/Immunetonsils   moderately Homo sapiens
Nervousbrain   moderately
 brainhindbraincerebellum moderately
 spinal cord   moderately
Reproductivefemale systemuterus  highly
 female systemplacenta  highly Homo sapiens
 male systemprostate  highly
Respiratorylung   highly
 respiratory tracttrachea  moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Muscularstriatumskeletal moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
Respiratoryalveolar macrophage Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal contains a leucine zipper transmembrane region, a cytosolic and an extracellular domain
  • C type lectin
  • a coiled-coil domain
  • a collagen domain
  • C-terminal C-type lectin/carbohydrate recognition domain, that interacts with specific glycans
  • several putative sites for N-glycosylation
  • a serine/threonine-rich region
  • a putative internalization signal
  • conjugated GlycoP
    mono polymer trimer
    HOMOLOGY
    interspecies ortholog to Colec12, Mus musculus
    homolog to si:ch211-212m21.5, Danio rerio
    ortholog to COLEC12, Pan troglodytes
    ortholog to Colec12, Rattus norvegicus
    Homologene
    FAMILY
  • family of class A scavenger receptors
  • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 2 membrane protein
    basic FUNCTION
  • involved in host defenses
  • might play important roles in host defenses and/or atherosclerosis formation
  • having scavenger function as to carbohydrate-containing ligands
  • may participate in removing oxidatively damaged or apoptotic cells
  • could be the receptor involved in the binding or clearing of Abeta by glial and vascular/perivascular cells in Alzheimer disease
  • mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein
  • predominantly mediated phagocytosis for fungi in vascular endothelia
  • may be playing a role in the clearance of amyloid beta in Alzheimer disease
  • shares structural features with both collectins and type A scavenger receptors
  • plays a role in the host defense system and in the clearance of glycoproteins from the blood
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens, sialyl Lewis X or a trisaccharide and asialo-orosomucoid
  • protein
  • fibrillar beta amyloid peptide
  • zymosan
  • binds via its lectin domain to desialyated Lewis X containing glycoproteins and it is able to facilitate internalization of bound ligands
  • cell & other
  • binding to carbohydrate antigens on microorganisms
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS