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FLASH GENE
Symbol COLEC12 contributors: shn - updated : 18-01-2011
HGNC name collectin sub-family member 12
HGNC id 16016
Location 18p11.32      Physical location : 319.355 - 500.729
Synonym name
  • collectin-12
  • collectin placenta protein 1
  • collectin placenta 1
  • scavenger receptor with C-type lectin
  • scavenger receptor collectin placenta 1
  • nurse cell scavenger receptor 2
  • scavenger receptor with C-type lectin
  • scavenger receptor class A member 4
  • Synonym symbol(s) SRCL, CLP1, CL-P1, hCL-P1, SCARA4, NSR2
    DNA
    TYPE functioning gene
    STRUCTURE 181.38 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map tel - COLEC12 - D18S1140 - D18S59 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 3134 81.4 742 - 2006 16868960
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
     vesselscapillary   
    Digestiveintestinelarge intestinecolon moderately
     intestinesmall intestine  highly
    Lymphoid/Immunetonsils   moderately Homo sapiens
    Nervousbrain   moderately
     brainhindbraincerebellum moderately
     spinal cord   moderately
    Reproductivefemale systemuterus  highly
     female systemplacenta  highly Homo sapiens
     male systemprostate  highly
    Respiratorylung   highly
     respiratory tracttrachea  moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Muscularstriatumskeletal moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    Respiratoryalveolar macrophage Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal contains a leucine zipper transmembrane region, a cytosolic and an extracellular domain
  • C type lectin
  • a coiled-coil domain
  • a collagen domain
  • C-terminal C-type lectin/carbohydrate recognition domain, that interacts with specific glycans
  • several putative sites for N-glycosylation
  • a serine/threonine-rich region
  • a putative internalization signal
  • conjugated GlycoP
    mono polymer trimer
    HOMOLOGY
    interspecies ortholog to Colec12, Mus musculus
    homolog to si:ch211-212m21.5, Danio rerio
    ortholog to COLEC12, Pan troglodytes
    ortholog to Colec12, Rattus norvegicus
    Homologene
    FAMILY
  • family of class A scavenger receptors
  • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 2 membrane protein
    basic FUNCTION
  • involved in host defenses
  • might play important roles in host defenses and/or atherosclerosis formation
  • having scavenger function as to carbohydrate-containing ligands
  • may participate in removing oxidatively damaged or apoptotic cells
  • could be the receptor involved in the binding or clearing of Abeta by glial and vascular/perivascular cells in Alzheimer disease
  • mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein
  • predominantly mediated phagocytosis for fungi in vascular endothelia
  • may be playing a role in the clearance of amyloid beta in Alzheimer disease
  • shares structural features with both collectins and type A scavenger receptors
  • plays a role in the host defense system and in the clearance of glycoproteins from the blood
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens, sialyl Lewis X or a trisaccharide and asialo-orosomucoid
  • protein
  • fibrillar beta amyloid peptide
  • zymosan
  • binds via its lectin domain to desialyated Lewis X containing glycoproteins and it is able to facilitate internalization of bound ligands
  • cell & other
  • binding to carbohydrate antigens on microorganisms
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS