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FLASH GENE
Symbol COLEC12 contributors: shn - updated : 18-01-2011
HGNC name collectin sub-family member 12
HGNC id 16016
Location 18p11.32      Physical location : 319.355 - 500.729
Synonym name
  • collectin-12
  • collectin placenta protein 1
  • collectin placenta 1
  • scavenger receptor with C-type lectin
  • scavenger receptor collectin placenta 1
  • nurse cell scavenger receptor 2
  • scavenger receptor with C-type lectin
  • scavenger receptor class A member 4
  • Synonym symbol(s) SRCL, CLP1, CL-P1, hCL-P1, SCARA4, NSR2
    DNA
    TYPE functioning gene
    STRUCTURE 181.38 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map tel - COLEC12 - D18S1140 - D18S59 - cen
    Physical map
    LOC388454 18 LOC388454 LOC260334 18p11 HSA18p11 beta-tubulin 4Q pseudogene IL9RP4 18p11.3 interleukin 9 receptor pseudogene 4 USP14 18p ubiquitin specific protease 14 (tRNA-guanine transglycosylase) THOC1 18p11.32 THO complex 1 COLEC12 18pter-p11.3 collectin sub-family member 12 LOC390821 18 LOC390821 CETN1 18p11.32 centrin, EF-hand protein, 1 CLUL1 18p11.32 clusterin-like 1 (retinal) TYMS 18p11.32 thymidylate synthetase HSRTSBETA 18p11.32 rTS beta protein YES1 18p11.31-p11.22 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 ADCYAP1 18p11.31 adenylate cyclase activating polypeptide 1 (pituitary) LOC388456 18 hypothetical gene supported by BC039671 C18orf2 18p11 chromosome 18 open reading frame 2 LOC390822 18 similar to RIKEN cDNA 4921525H23 FLJ23017 HEC 18p11.31 similar to RIKEN cDNA 4921525H23 LOC388457 18 hypothetical gene supported by BC006008 KIAA0650 18p11.31 hypothetical gene supported by BC006008 EMILIN2 18p11.3 elastin microfibril interfacer 2 LPIN2 18p11.31 lipin 2 LOC390823 18 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) MYOM1 18p11.32-p11.31 myomesin 1 (skelemin) 185kDa MRCL3 18p11.31 myosin regulatory light chain MRCL3 MRLC2 18p11.31 myosin regulatory light chain MRLC2 LOC204777 18p11.31 similar to Immunoglobulin lambda-like polypeptide 1 precursor (Immunoglobulin-related 14.1 protein) (Immunoglobulin omega polypeptide) (Lambda 5) (CD179b antigen) TGIF 18p11.3 TGFB-induced factor (TALE family homeobox) LOC390824 18 similar to hypothetical protein BC007436 DLGAP1 18p11.3 discs, large (Drosophila) homolog-associated protein 1 MGC11082 18p11.31 hypothetical protein MGC11082
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 3134 81.4 742 - 2006 16868960
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
     vesselscapillary   
    Digestiveintestinelarge intestinecolon moderately
     intestinesmall intestine  highly
    Lymphoid/Immunetonsils   moderately Homo sapiens
    Nervousbrain   moderately
     brainhindbraincerebellum moderately
     spinal cord   moderately
    Reproductivefemale systemuterus  highly
     female systemplacenta  highly Homo sapiens
     male systemprostate  highly
    Respiratorylung   highly
     respiratory tracttrachea  moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Muscularstriatumskeletal moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    Respiratoryalveolar macrophage Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal contains a leucine zipper transmembrane region, a cytosolic and an extracellular domain
  • C type lectin
  • a coiled-coil domain
  • a collagen domain
  • C-terminal C-type lectin/carbohydrate recognition domain, that interacts with specific glycans
  • several putative sites for N-glycosylation
  • a serine/threonine-rich region
  • a putative internalization signal
  • conjugated GlycoP
    mono polymer trimer
    HOMOLOGY
    interspecies ortholog to Colec12, Mus musculus
    homolog to si:ch211-212m21.5, Danio rerio
    ortholog to COLEC12, Pan troglodytes
    ortholog to Colec12, Rattus norvegicus
    Homologene
    FAMILY
  • family of class A scavenger receptors
  • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 2 membrane protein
    basic FUNCTION
  • involved in host defenses
  • might play important roles in host defenses and/or atherosclerosis formation
  • having scavenger function as to carbohydrate-containing ligands
  • may participate in removing oxidatively damaged or apoptotic cells
  • could be the receptor involved in the binding or clearing of Abeta by glial and vascular/perivascular cells in Alzheimer disease
  • mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein
  • predominantly mediated phagocytosis for fungi in vascular endothelia
  • may be playing a role in the clearance of amyloid beta in Alzheimer disease
  • shares structural features with both collectins and type A scavenger receptors
  • plays a role in the host defense system and in the clearance of glycoproteins from the blood
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens, sialyl Lewis X or a trisaccharide and asialo-orosomucoid
  • protein
  • fibrillar beta amyloid peptide
  • zymosan
  • binds via its lectin domain to desialyated Lewis X containing glycoproteins and it is able to facilitate internalization of bound ligands
  • cell & other
  • binding to carbohydrate antigens on microorganisms
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS