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FLASH GENE
Symbol TRPV2 contributors: mct - updated : 28-02-2015
HGNC name transient receptor potential cation channel, subfamily V, member 2
HGNC id 18082
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three ankyrin repeats domain at the N terminal
  • six transmembrane domains
  • a putative pore-loop region between TM5 and TM6
  • a C terminal cytoplasmic tail
    • HOMOLOGY
    interspecies homolog to murine Vrl1
    Homologene
    FAMILY
  • transient receptor family
  • TRPV subfamily
    • CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text translocates from the cytoplasm to the plasma membrane upon ligand stimulation
    basic FUNCTION
  • may be involved in transduction of high-temperature heat responses in sensory ganglia
  • TRPV2 channel is associated with changes in blood pressure and cardiac function depending on how and where the channel is activated
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    text
  • ion transporter
  • heat-gated ion channel
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with a c-Amp-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ABCD3
    • cell & other
    REGULATION
    activated by high temperatures (higher than 52 degrees Celsius)
    Other not activated by capsaicin
    regulated, at least in part, by IGFI, PDGF and neuropeptide head activator
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascular  
    TRPV1 and TRPV2 channels are targets for therapeutic agents of cardiovascular diseases
    ANIMAL & CELL MODELS