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FLASH GENE

Symbol

TRPV2

contributors: mct - updated : 28-02-2015

HGNC name	transient receptor potential cation channel, subfamily V, member 2
HGNC id	18082

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17p11.2      Physical location : 16.318.855 - 16.340.315
Synonym name	vanilloid receptor-like
	Osm-9-like TRP channel 2
Synonym symbol(s)	VRL, OTRPC2, VRL-1, VRL1, MGC12549

DNA

TYPE	functioning gene
STRUCTURE	21.43 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016113 15 - 2797 NP_057197 - 764 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly Nervous brain         Skin/Tegument skin       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three ankyrin repeats domain at the N terminal
	six transmembrane domains
	a putative pore-loop region between TM5 and TM6
	a C terminal cytoplasmic tail

HOMOLOGY

interspecies

homolog to murine Vrl1

Homologene

FAMILY	transient receptor family
	TRPV subfamily

CATEGORY

receptor , transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
text	translocates from the cytoplasm to the plasma membrane upon ligand stimulation

basic FUNCTION	may be involved in transduction of high-temperature heat responses in sensory ganglia
	TRPV2 channel is associated with changes in blood pressure and cardiac function depending on how and where the channel is activated

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

nervous system

text	ion transporter
	heat-gated ion channel

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacts with a c-Amp-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ABCD3

cell & other

REGULATION

activated by

high temperatures (higher than 52 degrees Celsius)

Other	not activated by capsaicin
	regulated, at least in part, by IGFI, PDGF and neuropeptide head activator

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular     TRPV1 and TRPV2 channels are targets for therapeutic agents of cardiovascular diseases

ANIMAL & CELL MODELS