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FLASH GENE

Symbol

ZNF423

contributors: mct/ - updated : 22-05-2015

HGNC name	zinc finger protein 423
HGNC id	16762

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NPHP14

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by RNA interference in neuroblastoma cells results in a growth advantage and resistance to RA-induced differentiation with poor outcome tumoral     --low   with NF1, in neuroblastomas with poor outcome

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Homozygous Zfp423 null mice are runted and ataxic, the cerebellum is underdeveloped, and the vermis is severely reduced
	Zfp423 null mice develop a profound hypoplasia of the cerebellar vermis, reminiscent of the Dandy-Walker malformation