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FLASH GENE
Symbol BDKRB1 contributors: mct - updated : 16-04-2020
HGNC name bradykinin receptor B1
HGNC id 1029
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor, lacking the Cter Arg
HOMOLOGY
Homologene
FAMILY
CATEGORY signaling cytokine , receptor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • playing a potentially protective role in the kidney against end stage renal disease (ESRD)
  • playing an important role in the control of pancreatic vascular homeostasis and insulin release, and in the pathogenesis of diabetes and related diseases
  • laminar shear stress (LSS) is a major determinant of functional BDKRB1 expression in endothelium
  • BDKRB1, BDKRB2 play an essential role in inflammatory process and cardiovascular homeostasis
  • participates in the modulation of insulin action in adipocytes, contributing to systemic insulin sensitivity and predisposition to obesity
  • G protein-coupled receptor with pro-inflammatory activity that is latent in healthy tissues but induced by tissue insult
  • plays an important role in hepatic steatosis development
  • inhibition of endocytosis, which stabilized BDKRB1 on the cell surface, inhibited BDKRB1 signaling, whereas BDKRB2 signaling was not perturbed
  • BDKRB1-mediated vasodilatation in healthy myometrial vessels that is absent in pre-eclampsia
  • regulates muscle-specific E3 ligases expression and is involved in skeletal muscle mass control
  • BDKRB1, APLNR are involved in a variety of important physiological processes, which share many similar characteristics in distribution and functions in the cardiovascular system
  • is a novel modulator that promotes adhesion of leukocytes to endothelial cells, critically enhancing the movement of neutrophils from the circulation to sites of inflammation
  • plays a critical role in inflammatory responses mediated by activation of the kallikrein-kinin system
  • may contribute to improve the host response against melanoma progression
  • bradykinin exerts its vascular actions via two types of receptors, the non-constitutively expressed bradykinin receptor type 1 (BDKRB1) and the constitutive type 2 receptor (BDKRB2)
  • BDKRB1 and the transient receptor potential ankyrin 1 (TRPA1) work as initiators and gatekeepers of nociception and inflammation
  • detrimental role of BDKRB1 in insulin resistance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • BDKRB1 homo-oligomerization is necessary for BDKRB1 maturation and trafficking to the cell surface
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • close relationship of BDKRB1 and CPM on the membrane is required for efficiently generatingoles in inflammation
  • up-regulation of BDRKB1 may contribute to acute inflammatory pain through TRPV1 activation
  • BDKRB1 function can be downregulated by BDKRB2 co-endocytosis and signaling
  • important role of the endothelial BDKRB1 in the vascular control by interfering with SLC7A1 expression, L-Arg uptake and nitric oxide (NO) release
  • BDKRB1 positively modulates both CPM expression and activity, suggesting that CPM-BDKRB1 interaction in membrane microdomains might affect enzyme activity, beyond interfering in receptors signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in subcutaneous white adipose tissue (sWAT) in patients with coronary artery disease (CAD)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum BDKRB1 levels may provide prognostic information and currently act as potential indicators for progression in atherosclerosis
    • Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    its inhibition can reduce BBB damage and cell invasion during autoimmune CNS disease and may offer a novel anti-inflammatory strategy for the treatment of MS
    miscelleaneousurinary 
    blockade of the BDKRB1 has significant potential for the treatment of glomerulonephritis
    ANIMAL & CELL MODELS
  • Bdkrb1 is upregulated by the oxidative stress in the brain of insulin-resistant rats and its activation causes stereotypic nocifensive behavior through the release of substance P, glutamate and NO