Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

BDKRB1

contributors: mct - updated : 16-04-2020

HGNC name	bradykinin receptor B1
HGNC id	1029

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Reproductive female system uterus cervix   highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor, lacking the Cter Arg

HOMOLOGY

Homologene

FAMILY

CATEGORY

signaling cytokine , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	playing a potentially protective role in the kidney against end stage renal disease (ESRD)
	playing an important role in the control of pancreatic vascular homeostasis and insulin release, and in the pathogenesis of diabetes and related diseases
	laminar shear stress (LSS) is a major determinant of functional BDKRB1 expression in endothelium
	BDKRB1, BDKRB2 play an essential role in inflammatory process and cardiovascular homeostasis
	participates in the modulation of insulin action in adipocytes, contributing to systemic insulin sensitivity and predisposition to obesity
	G protein-coupled receptor with pro-inflammatory activity that is latent in healthy tissues but induced by tissue insult
	plays an important role in hepatic steatosis development
	inhibition of endocytosis, which stabilized BDKRB1 on the cell surface, inhibited BDKRB1 signaling, whereas BDKRB2 signaling was not perturbed
	BDKRB1-mediated vasodilatation in healthy myometrial vessels that is absent in pre-eclampsia
	regulates muscle-specific E3 ligases expression and is involved in skeletal muscle mass control
	BDKRB1, APLNR are involved in a variety of important physiological processes, which share many similar characteristics in distribution and functions in the cardiovascular system
	is a novel modulator that promotes adhesion of leukocytes to endothelial cells, critically enhancing the movement of neutrophils from the circulation to sites of inflammation
	plays a critical role in inflammatory responses mediated by activation of the kallikrein-kinin system
	may contribute to improve the host response against melanoma progression
	bradykinin exerts its vascular actions via two types of receptors, the non-constitutively expressed bradykinin receptor type 1 (BDKRB1) and the constitutive type 2 receptor (BDKRB2)
	BDKRB1 and the transient receptor potential ankyrin 1 (TRPA1) work as initiators and gatekeepers of nociception and inflammation
	detrimental role of BDKRB1 in insulin resistance

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

BDKRB1 homo-oligomerization is necessary for BDKRB1 maturation and trafficking to the cell surface

INTERACTION

DNA

RNA

small molecule

protein	close relationship of BDKRB1 and CPM on the membrane is required for efficiently generatingoles in inflammation
	up-regulation of BDRKB1 may contribute to acute inflammatory pain through TRPV1 activation
	BDKRB1 function can be downregulated by BDKRB2 co-endocytosis and signaling
	important role of the endothelial BDKRB1 in the vascular control by interfering with SLC7A1 expression, L-Arg uptake and nitric oxide (NO) release
	BDKRB1 positively modulates both CPM expression and activity, suggesting that CPM-BDKRB1 interaction in membrane microdomains might affect enzyme activity, beyond interfering in receptors signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in subcutaneous white adipose tissue (sWAT) in patients with coronary artery disease (CAD)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	serum BDKRB1 levels may provide prognostic information and currently act as potential indicators for progression in atherosclerosis
Therapy target
	System Type Disorder Pubmed immunology inflammatory   its inhibition can reduce BBB damage and cell invasion during autoimmune CNS disease and may offer a novel anti-inflammatory strategy for the treatment of MS miscelleaneous urinary   blockade of the BDKRB1 has significant potential for the treatment of glomerulonephritis

ANIMAL & CELL MODELS

Bdkrb1 is upregulated by the oxidative stress in the brain of insulin-resistant rats and its activation causes stereotypic nocifensive behavior through the release of substance P, glutamate and NO