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FLASH GENE
Symbol CPA4 contributors: - updated : 14-04-2005
HGNC name carboxypeptidase A4
HGNC id 15740
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text member of a cluster of carboxypeptidase on chromosome 7 with CPA1, CPA2 and CPA5
STRUCTURE 31.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence   ALU
text structure sequence SINE/ ALU in the first intron
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
Epithelialsensoryvisual  
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentmelanocyte
cell lineage
cell lines
fluid/secretion
at STAGE
IMPRINTING paternally
text paternally imprinted in fetal heart, lung, liver, intestine, kidney adrenal gland, spleen (but not in brain) and in benign hypertrophic prostate
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leader segment
  • an activation peptide and a carboxypeptidase moiety with a zinc binding site
    • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    intraspecies paralog to CPA1
    Homologene
    FAMILY zinc carboxypeptidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION cleaving substrates with C terminal hydrophobic residues
    CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    histone hyperacetylation pathway
    a component CPA4/latexin complex
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    inhibited by LXN
    ASSOCIATED DISORDERS
    corresponding disease(s) SRS7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS