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FLASH GENE
Symbol FOXE3 contributors: mct/npt - updated : 26-10-2018
HGNC name forkhead box E3
HGNC id 3808
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a forkhead (FH,winged helix) domain
  • two loops-wings on the C-terminal side of helix-turn-helix homeo domain
    • HOMOLOGY
    interspecies homolog to Drosophila homeo forkhead DNA binding domain
    Homologene
    FAMILY
  • HNF-3 forkhead family of transcriptional activator
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • closure of the lens vesicle, promoting survival and proliferation while preventing epithelium differentiation
  • transcription factor essential to lens development (Reis 2010)
  • lens-specific transcription factor that has been associated with anterior segment ocular dysgenesis
    • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • PITX3 directly regulates FOXE3 during early lens development
  • DNAJB1 is a transcriptional target of FOXE3 in a novel pathway that is crucial for the development of the anterior segment of the eye
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ASMD5 , APKC , CTRCT34
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    dyl ( mice)