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FLASH GENE
Symbol FOXE3 contributors: mct/npt - updated : 26-10-2018
HGNC name forkhead box E3
HGNC id 3808
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyelens   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text developing eyelids, developing eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a forkhead (FH,winged helix) domain
  • two loops-wings on the C-terminal side of helix-turn-helix homeo domain
    • HOMOLOGY
    interspecies homolog to Drosophila homeo forkhead DNA binding domain
    Homologene
    FAMILY
  • HNF-3 forkhead family of transcriptional activator
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • closure of the lens vesicle, promoting survival and proliferation while preventing epithelium differentiation
  • transcription factor essential to lens development (Reis 2010)
  • lens-specific transcription factor that has been associated with anterior segment ocular dysgenesis
    • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • PITX3 directly regulates FOXE3 during early lens development
  • DNAJB1 is a transcriptional target of FOXE3 in a novel pathway that is crucial for the development of the anterior segment of the eye
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ASMD5 , APKC , CTRCT34
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    dyl ( mice)