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FLASH GENE
Symbol C1QTNF3 contributors: mct/npt/pgu - updated : 09-11-2009
HGNC name C1q and tumor necrosis factor related protein 3
HGNC id 14326
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a collagen triple helix repeat (Gly-X-Y repeats) at the N terminus
  • a complement factor C1q globular domain at the C terminus
  • HOMOLOGY
    interspecies ortholog to murine Cors26
    intraspecies homolog to ACRP30
    Homologene
    FAMILY
  • C1q/TNF-alpha molecular superfamily
  • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • adipocytokine that may play an important role in skeletal development
  • exerts anti-inflammatory properties and is expressed in monocytic cells
  • acting as a regulator of angiogenic processes, and may be involved as a novel angiogenic factor in the formation of neointima following angioplasty
  • new adipokine that differentially regulates the secretion of classical adipokines, with marked differences between the human and the murine systems (basal adipokine secretion is influenced by the BMI)
  • circulate in the blood and is potential endocrine hormone
  • is linked to hepatic glucose metabolism and a novel adipokine
  • stimulates chondrogenic precursor cell proliferation and promotes angiogenesis
  • metabolic regulator of glucose homeostasis
  • acts directly on liver cells, independent of insulin, to suppress gluconeogenic gene expression and glucose production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text skeletal development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS