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FLASH GENE
Symbol C1QTNF3 contributors: mct/npt/pgu - updated : 09-11-2009
HGNC name C1q and tumor necrosis factor related protein 3
HGNC id 14326
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon   Homo sapiens
 intestinesmall intestine  highly Homo sapiens
Endocrinepancreas   highly Homo sapiens
Lymphoid/Immunethymus   moderately Homo sapiens
Nervousbrain   moderately Homo sapiens
Reproductivefemale systemovary  moderately Homo sapiens
Urinarykidney   moderately Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  predominantly Homo sapiens
Connectivecartilage   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Lymphoid/Immunedendritic cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text prechondrocytic cell of cartilage
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a collagen triple helix repeat (Gly-X-Y repeats) at the N terminus
  • a complement factor C1q globular domain at the C terminus
  • HOMOLOGY
    interspecies ortholog to murine Cors26
    intraspecies homolog to ACRP30
    Homologene
    FAMILY
  • C1q/TNF-alpha molecular superfamily
  • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • adipocytokine that may play an important role in skeletal development
  • exerts anti-inflammatory properties and is expressed in monocytic cells
  • acting as a regulator of angiogenic processes, and may be involved as a novel angiogenic factor in the formation of neointima following angioplasty
  • new adipokine that differentially regulates the secretion of classical adipokines, with marked differences between the human and the murine systems (basal adipokine secretion is influenced by the BMI)
  • circulate in the blood and is potential endocrine hormone
  • is linked to hepatic glucose metabolism and a novel adipokine
  • stimulates chondrogenic precursor cell proliferation and promotes angiogenesis
  • metabolic regulator of glucose homeostasis
  • acts directly on liver cells, independent of insulin, to suppress gluconeogenic gene expression and glucose production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text skeletal development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS