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FLASH GENE

Symbol

C1QTNF3

contributors: mct/npt/pgu - updated : 09-11-2009

HGNC name	C1q and tumor necrosis factor related protein 3
HGNC id	14326

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	25.36 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_030945 6 splicing 3570 NP_112207 26 246 - 2010 20952387 CTRP3A protein sequence is highly conserved throughout vertebrate evolution, with amino acid identity ranging from 78 to 99p100 CTRP3A interacted with CTRP3B only when they were co-expressed in the same cell NM_181435 6 splicing 3789 NP_852100 - 319 - 2010 20952387 no collagen domain CTRP3B having a larger exon 1 due to the retention of 219 nucleotides from the intron 1 sequence an extra 73 AAs in the N terminus, which contains a highly conserved N-linked glycosylation site CTRP3A interacted with CTRP3B only when they were co-expressed in the same cell

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Homo sapiens   intestine small intestine     highly Homo sapiens Endocrine pancreas       highly Homo sapiens Lymphoid/Immune thymus       moderately Homo sapiens Nervous brain       moderately Homo sapiens Reproductive female system ovary     moderately Homo sapiens Urinary kidney       moderately Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     predominantly Homo sapiens Connective cartilage

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Lymphoid/Immune dendritic cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	prechondrocytic cell of cartilage

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a collagen triple helix repeat (Gly-X-Y repeats) at the N terminus
	a complement factor C1q globular domain at the C terminus

HOMOLOGY

interspecies

ortholog to murine Cors26

intraspecies

homolog to ACRP30

Homologene

FAMILY

C1q/TNF-alpha molecular superfamily

CATEGORY

enzyme , immunity/defense

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	adipocytokine that may play an important role in skeletal development
	exerts anti-inflammatory properties and is expressed in monocytic cells
	acting as a regulator of angiogenic processes, and may be involved as a novel angiogenic factor in the formation of neointima following angioplasty
	new adipokine that differentially regulates the secretion of classical adipokines, with marked differences between the human and the murine systems (basal adipokine secretion is influenced by the BMI)
	circulate in the blood and is potential endocrine hormone
	is linked to hepatic glucose metabolism and a novel adipokine
	stimulates chondrogenic precursor cell proliferation and promotes angiogenesis
	metabolic regulator of glucose homeostasis
	acts directly on liver cells, independent of insulin, to suppress gluconeogenic gene expression and glucose production

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	skeletal development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS