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FLASH GENE
Symbol FOXF1 contributors: mct/npt - updated : 07-04-2014
HGNC name forkhead box F1
HGNC id 3809
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a forkhead (FH, winged helix) domain
  • two loops-wings on the C-terminal side of helix-turn-helix homeo domain
    • HOMOLOGY
    interspecies homolog to Drosophila homeo fork head DNA binding domain
    Homologene
    FAMILY
  • HNF-3 forkhead family of transcriptional activator
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • embryonic transcriptional regulator of pulmonary genes
  • playing a crucial role in lung and intrinsic pulmonary vascular development (Stankiewicz 2009)
  • with FOXL1, are mediators of the Hh (endoderm) to mesoderm signaling pathway (Madison 2009)
  • mesenchymal target of hedgehog signaling, known to regulate mesenchymal-epithelial interactions during lung development
  • potential tumor suppressor gene with an essential role in preventing DNA rereplication to maintain genomic stability, which is frequently inactivated in breast cancer through the epigenetic mechanism
  • is required for normal development of gastrointestinal smooth muscle
  • FOXF1 and SRF synergistically activate the telokin promoter and FOXF1 promotes SRF-myocardin binding
  • in smooth muscle cells is required for the development and normal physiological function of the gastrointestinal tract
  • is not only important for visceral smooth muscle development but also for maintaining expression of contractile proteins in adult gastrointestinal smooth muscle tissues
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • HOXA13 directly regulates TEK and FOXF1 in the placental labyrinth endothelia
  • directly binds to and activates the telokin (MYLK) promoter
  • also directly binds to serum response factor (SRF) and myocardin-related transcription factors (MRTFs)
  • FOXF1 and FOXQ1 directly bind to distinct regions of MYOCD
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACDMPV
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    predominantly silenced in breast and colorectal cancer cell lines with inactive T53¨
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Foxf1 heterozygous mice display abnormalities in lung and gallbladder development
  • Foxf1 deletion from smooth muscle cells causes esophageal defects in newborn mice