basic FUNCTION
| embryonic transcriptional regulator of pulmonary genes |
|
playing a crucial role in lung and intrinsic pulmonary vascular development (Stankiewicz 2009) |
|
with FOXL1, are mediators of the Hh (endoderm) to mesoderm signaling pathway (Madison 2009) |
|
mesenchymal target of hedgehog signaling, known to regulate mesenchymal-epithelial interactions during lung development |
|
potential tumor suppressor gene with an essential role in preventing DNA rereplication to maintain genomic stability, which is frequently inactivated in breast cancer through the epigenetic mechanism |
|
is required for normal development of gastrointestinal smooth muscle |
|
FOXF1 and SRF synergistically activate the telokin promoter and FOXF1 promotes SRF-myocardin binding |
|
in smooth muscle cells is required for the development and normal physiological function of the gastrointestinal tract |
|
is not only important for visceral smooth muscle development but also for maintaining expression of contractile proteins in adult gastrointestinal smooth muscle tissues |