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FLASH GENE

Symbol

DENND4A

contributors: - updated : 30-03-2006

HGNC name	DENN/MADD domain containing 4A
HGNC id	24321

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node           spleen           thymus

cells

System Cell Pubmed Species Stage Rna symbol Lymhoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a DNA binding region
	a ISRE (interferon-stimulated response element) -binding domain
	a tripartite DENN domain,a nuclear localization signal
	two PPR and a calmodulin- binding domain

secondary structure

a putative alpha-helical DNA binding region

HOMOLOGY

Homologene

FAMILY

IRLB family

CATEGORY

DNA associated , transcription factor , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	playing a role in regulation of enter cell cycle and begin DNA replication
	transcription factor governing expression of oncogene MYC

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to interferon-stimulated response element ISRE of the myc promoter

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS