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FLASH GENE
Symbol DENND4A contributors: - updated : 30-03-2006
HGNC name DENN/MADD domain containing 4A
HGNC id 24321
DNA
TYPE functioning gene
STRUCTURE 131.00 kb     33 Exon(s)
regulatory sequence Promoter
Binding site   transcription factor
text structure transcription factor binding site for E2F,CRE,SRE,ER and NFKB
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen    
 thymus    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymhoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DNA binding region
  • a ISRE (interferon-stimulated response element) -binding domain
  • a tripartite DENN domain,a nuclear localization signal
  • two PPR and a calmodulin- binding domain
  • secondary structure
  • a putative alpha-helical DNA binding region
  • HOMOLOGY
    Homologene
    FAMILY IRLB family
    CATEGORY DNA associated , transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing a role in regulation of enter cell cycle and begin DNA replication
  • transcription factor governing expression of oncogene MYC
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to interferon-stimulated response element ISRE of the myc promoter
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS