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FLASH GENE

Symbol

FYCO1

contributors: mct - updated : 15-01-2025

HGNC name	FYVE and coiled-coil domain containing 1
HGNC id	14673

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Cardiovascular heart       highly Endocrine parathyroid       highly Nervous brain         Reproductive female system uterus cervix   highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal RUN domain
	a C terminal FYVE domain with two coiled-coid domain in-between

HOMOLOGY

Homologene

FAMILY	ezrin/radixin/moesin family
	PI(3)P-binding protein family

CATEGORY

transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome
	intracellular,cytoplasm,cytosolic,vesicle
	intracellular,cytoplasm,cytoskeleton,microtubule
text	colocalize to microtubules and found adjacent to Golgi, but primarily colocalize to autophagosomes

basic FUNCTION	promotes microtubule (MT) plus end-directed transport of autophagic vesicles
	functions as an adapter linking autophagosomes to microtubule plus end-directed molecular motors
	associated with the exterior of autophagosomes and mediating microtubule plus-end-directed vesicle transport
	involved in lens development and transparency

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds to both MAP1LC3A, PtdIns(3)P and RAB7A, and contains a domain responsible for microtubule plus end-dependent transport
	NINL enhanced the interaction between RAB7A and FYCO1, thus accelerated autophagic flux and the formation of autophagolysosome

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ARCC4

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS