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FLASH GENE
Symbol NUSAP1 contributors: mct/shn - updated : 23-09-2012
HGNC name nucleolar and spindle associated protein 1
HGNC id 18538
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SAP-like domain, fot the interaction with chromatin in interphase cells
  • a C-terminal microtubule-binding domain
    • HOMOLOGY
    interspecies ortholog to Nusap1, Mus musculus
    ortholog to nusap1, Danio rerio
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleolus
    text
  • localizes to chromosome arms and chromosome-proximal microtubules during mitosis and to the nucleus, with enrichment in the nucleoli, during interphase (
    • basic FUNCTION
  • a crucial role in spindle microtubule organization
  • its degradation is important to exit from mitosis
  • microtubule-associated protein that plays an important role in spindle assembly
  • role in connecting apoptosis with cell migration, but also is potentially involved in morphogenesis in vertebrates
  • microtubule-stabilizing protein that localizes to chromosome arms and chromosome-proximal microtubules during mitosis and to the nucleus, with enrichment in the nucleoli, during interphase
  • role in gene expression or DNA damage response
    • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • dsDNA
    • RNA
    small molecule
    protein
  • NSUN2
  • novel direct target gene of MYC
    • cell & other
  • microtubules
    • REGULATION
    Other cell cycle regulated, restricted to late S/G2 and M phases, undetectable in G1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS