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FLASH GENE
Symbol ZC3HAV1 contributors: mct - updated : 10-01-2018
HGNC name zinc finger CCCH type, antiviral 1
HGNC id 23721
Location 7q33      Physical location : 138.728.267 - 138.794.465
Synonym name
  • zinc finger antiviral protein
  • CCCH-type zinc finger antiviral protein
  • Poly(ADP-ribose) polymerase-13
    • Synonym symbol(s) ZAP, FLB6421, ZC3HDC2, FLJ13288, MGC48898, ARTD13, FLB6421, PARP13, ZC3H2, ZC3HDC2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE tail to tail
    STRUCTURE 66.20 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 7190 - 902 - 2015 26129669
    9 - 3218 77 699 - 2015 26129669
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselsaorta   
    Endocrinethyroid    
    Reproductivefemale systemuterus   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver, stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • lacks the structural requirements for ADP-ribosyltransferase activity
    • HOMOLOGY
    interspecies homolog to rattus Zap
    homolog to murine Zc3hav1
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • is an RNA-binding protein that regulates the stability and translation of specific mRNAs, and modulates the miRNA silencing pathway to globally affect miRNA targets
  • these functions of ZC3HAV1 are important components of the cellular response to stress
  • likely inhibits the retrotransposition of LINE and Alu elements
  • association of the ZC3HAV1 ribonucleoprotein particle with many interferon-stimulated gene products indicates it may be a key player in the interferon response
  • is a host factor that specifically inhibits the replication of certain viruses by binding to viral mRNAs and repressing the translation and/or promoting the degradation of target mRNA
  • is a host antiviral factor that specifically inhibits the replication of certain viruses, including HIV-1, Sindbis virus, and Ebola virus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binds directly to specific viral mRNAs and recruits cellular mRNA degradation machinery to degrade the target RNA
    small molecule
    protein
  • is a key regulator of DDX58 signaling during the innate antiviral immune response
  • DHX30 is required for optimal antiviral activity of ZC3HAV1
  • function for MATR3 as a negative regulator of the ZC3HAV1-mediated restriction of retroviruses
  • TRIM25 is a bona fide ZC3HAV1 cofactor that leads to increased ZC3HAV1 modification enhancing its translational inhibition activity
  • TRIM25, a ubiquitin E3 ligase, is required for the antiviral activity of ZC3HAV1
    • cell & other
    REGULATION
    Phosphorylated by by glycogen synthase kinase 3beta (GSK3B)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS