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FLASH GENE
Symbol PARD6G contributors: - updated : 09-04-2002
HGNC name par-6 partitioning defective 6 homolog gamma (C. elegans)
HGNC id 16076
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a OPR domain
  • a DPZ domain
  • a CRIB-like motif
    • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Pard6g
    intraspecies homolog to PARD6A
    homolog to PARD6B
    Homologene
    FAMILY PARD6 proteins family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION
    text colocalized to membrane ruffles
    basic FUNCTION
  • playing a role in the cell polarization and asymmetric cell division
  • activating Rac and CDC42 to a PKC signaling
    • CELLULAR PROCESS cell cycle, division
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a quaternary complex with protein kinase C zeta (PRKCS), PARD3 and CDC42
    • INTERACTION
    DNA
    RNA
    small molecule
    protein GTP bound RAC, CDC42, PKC iola/lambda and PKC zeta
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS