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FLASH GENE

Symbol

PARD6G

contributors: - updated : 09-04-2002

HGNC name	par-6 partitioning defective 6 homolog gamma (C. elegans)
HGNC id	16076

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	90.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a OPR domain
	a DPZ domain
	a CRIB-like motif

mono polymer

heteromer , tetramer

HOMOLOGY

interspecies

homolog to murine Pard6g

intraspecies	homolog to PARD6A
	homolog to PARD6B

Homologene

FAMILY

PARD6 proteins family

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION
text	colocalized to membrane ruffles

basic FUNCTION	playing a role in the cell polarization and asymmetric cell division
	activating Rac and CDC42 to a PKC signaling

CELLULAR PROCESS	cell cycle, division
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

forming a quaternary complex with protein kinase C zeta (PRKCS), PARD3 and CDC42

INTERACTION

DNA

RNA

small molecule

protein

GTP bound RAC, CDC42, PKC iola/lambda and PKC zeta

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS