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FLASH GENE
Symbol PARD6G contributors: - updated : 09-04-2002
HGNC name par-6 partitioning defective 6 homolog gamma (C. elegans)
HGNC id 16076
Location 18q23      Physical location : 77.915.118 - 78.005.397
Synonym name
  • par-6 (partitioning defective 6, C.elegans) homolog gamma
  • partitioning defective 6 homolog gamma
    • Synonym symbol(s) PAR-6G, FLJ45701
    DNA
    TYPE functioning gene
    STRUCTURE 90.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a OPR domain
  • a DPZ domain
  • a CRIB-like motif
    • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Pard6g
    intraspecies homolog to PARD6A
    homolog to PARD6B
    Homologene
    FAMILY PARD6 proteins family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION
    text colocalized to membrane ruffles
    basic FUNCTION
  • playing a role in the cell polarization and asymmetric cell division
  • activating Rac and CDC42 to a PKC signaling
    • CELLULAR PROCESS cell cycle, division
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a quaternary complex with protein kinase C zeta (PRKCS), PARD3 and CDC42
    • INTERACTION
    DNA
    RNA
    small molecule
    protein GTP bound RAC, CDC42, PKC iola/lambda and PKC zeta
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS