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FLASH GENE
Symbol METAP1 contributors: npt - updated : 03-01-2008
HGNC name methionyl aminopeptidase 1
HGNC id 15789
Location 4q22.3      Physical location : 99.916.787 - 99.983.959
Synonym name peptidase M 1
Synonym symbol(s) KIAA0094, DKFZp781C0419
EC.number 3.4.11.18
DNA
TYPE functioning gene
STRUCTURE 27.40 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2835 43.2 386 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal extended strings of basic and acidic residues
  • a C terminal catalytic domain
  • HOMOLOGY
    Homologene
    FAMILY
  • peptidase M24A family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • protecting the alpha subunit of eIF from inhibitory phosphorylation
  • removing the N-terminal MET residue from nascent proteins
  • CELLULAR PROCESS protein, post translation
    protein, degradation
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Co2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS