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FLASH GENE

Symbol

GPLD1

contributors: mct - updated : 07-06-2016

HGNC name	glycosylphosphatidylinositol specific phospholipase D1
HGNC id	4459

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   hyperexpression may be associated with tumor malignancy constitutional     --low   down-regulation of GPLD1 protein may be involved in prion propagation in the brains of prion diseases constitutional     --low   in human CJD patients

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Gpld1 was dramatically down-regulated in the brains of scrapie-infected mice, especially in the caveolin-enriched membrane fractions