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FLASH GENE

Symbol

GPLD1

contributors: mct - updated : 07-06-2016

HGNC name	glycosylphosphatidylinositol specific phospholipase D1
HGNC id	4459

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Homo sapiens Nervous brain         Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Amphiphilic
STRUCTURE

motifs/domains

integrin alpha (beta propellor repeats), FG-GAP

HOMOLOGY

Homologene

FAMILY

phospholipase D family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	hydrolyzing the inositol phosphate linkage in proteins anchored by phosphatidyl inositol glycans, releasing these proteins from membrane
	widely implicated in the generation of Phosphatidic acid (PA) needed for MTOR activation, it is becoming clear that PA generated via the LPAAT and DGK pathways is also involved in the regulation of MTOR
	strictly specific enzyme for GPI anchors
	may be involved in modulating the inflammatory process during scrapie disease

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	associated in serum with HDL
	cell-specific GPLD1- or peptidase-dependent pathways for PRSS8 secretion may control PRSS8 functions in a tissue-specific manner
	a critical component of RAS signaling in human cancer cells is the activation of GPLD1
	essential role for GPLD1 in the recruitment of VAT1 to membranes in human neutrophils
	Erk activity is governed by GPLD1 activity and regulates the tyrosine phosphorylation of PXN, potentially explaining its role in cell motility
	mediates STAR protein and aldosterone synthase (CYP11B2) expression via increasing the phosphorylation (activation) of their regulatory transcription factors
	reciprocal regulation of GPLD1 by PRKAA1 and regulation of PRKAA1 by GPLD1 and phosphatidic acid (PA)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   hyperexpression may be associated with tumor malignancy constitutional     --low   down-regulation of GPLD1 protein may be involved in prion propagation in the brains of prion diseases constitutional     --low   in human CJD patients

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Gpld1 was dramatically down-regulated in the brains of scrapie-infected mice, especially in the caveolin-enriched membrane fractions