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FLASH GENE
Symbol RASD1 contributors: mct/npt - updated : 24-04-2009
HGNC name RAS, dexamethasone-induced 1
HGNC id 15828
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • P loop
  • guanine base-binding loops
  • C terminal farnesylation site, an extended C terminus that is found to interact with the PTB domain of NOS1AP (Lau 2008)
    • HOMOLOGY
    interspecies homolog to murine Rasd1
    Homologene
    FAMILY
  • small GTPase superfamily
  • RasD family
    • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text found in the nucleus (Lau 2008)
    basic FUNCTION
  • playing a role in cell adhesion, extra-cellular matrix interactions, and in dexamethasone-induced alterations in cell morphology
  • acting to modulate the activation of adenylyl cyclase (ADCY2) in an indirect fashion by inhibiting both Gbetagamma- and PKC-stimulated ADCY2 activity and involved in signal transduction (Nguyen 2006)
  • physiologic Nitris oxide (No) effector and anchoring of neuronal Nitric oxide synthase to specific targets is a mechanism by which NO signaling is enhanced (Fang 2000)
  • functions as a suppressor of APBB1-APP-mediated transcription (Lau 2008)
  • brain-enriched member of the Ras family of small monomeric G proteins (Fang 2000)
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • with NOS1AP form a ternary complex that enhances the ability of neuronal nitric oxide synthase to activate RASD1 (Fang 2000)
  • with RASD1, RASD2 define a new group of Ras-like monomeric G proteins (Thapliyal 2008)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to APBB1 PTB2 domain and potently suppresses the APBB1-APP-mediated transcription (Lau 2008)
  • interacting with NOS1AP (Lau 2008)
  • RASD1 with RASD2 modulate Ca(2+) influx through Ca(V)2.2 channels under more physiological conditions and thereby influence Ca(2+)-dependent events such as neurosecretion (Thapliyal 2008)
    • cell & other
    REGULATION
    activated by dexamethasone
    by NO (nitric oxide) donors as well as by NMDA receptor-stimulated NO synthesis in cortical neurons (Fang 2000)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS