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FLASH GENE

Symbol

RASD1

contributors: mct/npt - updated : 24-04-2009

HGNC name	RAS, dexamethasone-induced 1
HGNC id	15828

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	1.96 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Binding site   HRE
text structure	a glucocorticoid response element (GRE) was identified in the 3'-flanking region (2.3 kb downstream of poly(A) signal)

MAPPING

cloned

Y

linked

N

status

confirmed

Map	see SMCR (phenotype)

regionally located

the Smith-Magenis critical region

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed RASD1 2 - 1758 31.5 281 - Fang (2000)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Endocrine neuroendocrine pituitary     highly   pancreas       highly Reproductive male system prostate     highly Respiratory lung       moderately Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	P loop
	guanine base-binding loops
	C terminal farnesylation site, an extended C terminus that is found to interact with the PTB domain of NOS1AP (Lau 2008)

HOMOLOGY

interspecies

homolog to murine Rasd1

Homologene

FAMILY	small GTPase superfamily
	RasD family

CATEGORY

signaling , receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus
text	found in the nucleus (Lau 2008)

basic FUNCTION	playing a role in cell adhesion, extra-cellular matrix interactions, and in dexamethasone-induced alterations in cell morphology
	acting to modulate the activation of adenylyl cyclase (ADCY2) in an indirect fashion by inhibiting both Gbetagamma- and PKC-stimulated ADCY2 activity and involved in signal transduction (Nguyen 2006)
	physiologic Nitris oxide (No) effector and anchoring of neuronal Nitric oxide synthase to specific targets is a mechanism by which NO signaling is enhanced (Fang 2000)
	functions as a suppressor of APBB1-APP-mediated transcription (Lau 2008)
	brain-enriched member of the Ras family of small monomeric G proteins (Fang 2000)

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	with NOS1AP form a ternary complex that enhances the ability of neuronal nitric oxide synthase to activate RASD1 (Fang 2000)
	with RASD1, RASD2 define a new group of Ras-like monomeric G proteins (Thapliyal 2008)

INTERACTION

DNA

RNA

small molecule

protein	binds to APBB1 PTB2 domain and potently suppresses the APBB1-APP-mediated transcription (Lau 2008)
	interacting with NOS1AP (Lau 2008)
	RASD1 with RASD2 modulate Ca(2+) influx through Ca(V)2.2 channels under more physiological conditions and thereby influence Ca(2+)-dependent events such as neurosecretion (Thapliyal 2008)

cell & other

REGULATION

activated by	dexamethasone
	by NO (nitric oxide) donors as well as by NMDA receptor-stimulated NO synthesis in cortical neurons (Fang 2000)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS