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FLASH GENE
Symbol ARAP2 contributors: mct/npt - updated : 27-04-2015
HGNC name ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
HGNC id 16924
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an ARF-GAP domain
  • a RHO-GAP domain lacking the predicted catalytic origine
  • a sterile alpha motif (SAM)
  • five pleckstrin homology (PH) domain
    • HOMOLOGY
    intraspecies paralog to CENTD2
    Homologene
    FAMILY
  • centaurin family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • PIP3 dependent GAP that regulates Arf, Rho and Cdc42 dependent cell activities
  • is an Arf6GAP that functions downstream of RHOA to regulate focal adhesion dynamics
  • slow cell spreading and promote Focal adhesions (FAs) dependent on its ArfGAP activity
  • reduced expression of ARAP2 resulted in an easily detectable increase in total RAC1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • changes in ARF6 and RAC1 activities are necessary but not sufficient for ARAP2 to promote the growth of Focal adhesions (FAs)
  • through regulation of ARF6, ARAP2 may control the recycling of integrins or other adhesion components, leading to a change in the adhesion turnover
  • ARAP2 and ACAP1 had opposing effects on apparent ITGB1 internalization
    • cell & other
  • targeted by phosphatidyl inositol (3,4,3) triphosphate
    • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS