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FLASH GENE

Symbol

ARAP2

contributors: mct/npt - updated : 27-04-2015

HGNC name	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
HGNC id	16924

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	178.35 kb     33 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015230 33 - 7375 NP_056045 194 1704 - 2006 17077126 variant 2 isoform b 20 initiation site 4820 100 876 - 2006 17077126 lacking the N terminus

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Digestive stomach       highly Endocrine thyroid         Nervous nerve       highly   spinal cord         Reproductive female system breast mammary gland   highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Epithelial secretory glandular endocrine   Lymphoid         Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an ARF-GAP domain
	a RHO-GAP domain lacking the predicted catalytic origine
	a sterile alpha motif (SAM)
	five pleckstrin homology (PH) domain

HOMOLOGY

intraspecies

paralog to CENTD2

Homologene

FAMILY

centaurin family

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	PIP3 dependent GAP that regulates Arf, Rho and Cdc42 dependent cell activities
	is an Arf6GAP that functions downstream of RHOA to regulate focal adhesion dynamics
	slow cell spreading and promote Focal adhesions (FAs) dependent on its ArfGAP activity
	reduced expression of ARAP2 resulted in an easily detectable increase in total RAC1

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	changes in ARF6 and RAC1 activities are necessary but not sufficient for ARAP2 to promote the growth of Focal adhesions (FAs)
	through regulation of ARF6, ARAP2 may control the recycling of integrins or other adhesion components, leading to a change in the adhesion turnover
	ARAP2 and ACAP1 had opposing effects on apparent ITGB1 internalization

cell & other

targeted by phosphatidyl inositol (3,4,3) triphosphate

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS