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FLASH GENE
Symbol GALR1 contributors: mct/npt - updated : 07-03-2009
HGNC name galanin receptor 1
HGNC id 4132
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • a lysosomal signal motif on the cytoplasmic terminus (Xia 2008)
    • HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
    • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text also coexpressed with GALN in ciliary epithelium
    basic FUNCTION
  • activating a variety of intracellular second-messenger pathways
  • tumor suppressor gene in HNSCC (head and neck squamous cell carcinoma) (Misawa 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    signaling through inhibition of adenylate cyclase
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • linked to voltage gated calcium channel
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL18QD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by promoter hypermethylation and associated with prognosis, in head and neck cancer (Misawa 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for growth hormone deficiency in 18q- syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS