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FLASH GENE

Symbol

GALR1

contributors: mct/npt - updated : 07-03-2009

HGNC name	galanin receptor 1
HGNC id	4132

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DEL18QD chromosome 18q distal deletion
Location	18q23      Physical location : 74.962.007 - 74.982.094
Synonym symbol(s)	GALNR1, GALNR, GAL1-R

DNA

TYPE	functioning gene
STRUCTURE	20.10 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed GALR1 3 - 2787 39 349 - Misawa (2008)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive male system prostate     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven transmembrane segments (7TM) receptor
	a lysosomal signal motif on the cytoplasmic terminus (Xia 2008)

HOMOLOGY

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

signaling cytokine , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	also coexpressed with GALN in ciliary epithelium

basic FUNCTION	activating a variety of intracellular second-messenger pathways
	tumor suppressor gene in HNSCC (head and neck squamous cell carcinoma) (Misawa 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal , signal transduction

signaling through inhibition of adenylate cyclase

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

linked to voltage gated calcium channel

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEL18QD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by promoter hypermethylation and associated with prognosis, in head and neck cancer (Misawa 2008)

Susceptibility

Variant & Polymorphism

Candidate gene	for growth hormone deficiency in 18q- syndrome
Marker
Therapy target

ANIMAL & CELL MODELS