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FLASH GENE
Symbol CAP2 contributors: mct - updated : 03-05-2017
HGNC name CAP, adenylate cyclase-associated protein, 2 (yeast)
HGNC id 20039
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Nervousbrain     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermis   Homo sapiens
Muscularstriatumskeletal   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal fragment of CAP2 interacts with actin, indicating that CAP2 has the capacity to bind to actin
    • HOMOLOGY
    interspecies homolog to murine Cap2
    ortholog to rattus Cap2
    ortholog to murine 2810452G09Rik
    homolog to Drosophila capt
    homolog to C.elegans F41G4.2a
    intraspecies homolog to CAP1
    Homologene
    FAMILY
  • CAP family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • found in the nucleus in undifferentiated myoblasts and at the M-line of differentiated myotubes
  • enriched in the nucleus, and sparse in the cytosol
    • basic FUNCTION
  • involved in establishment and/or maintenance of cell polarity
  • having a regulatory bifunctional role
  • C-terminal fragment of CAP2 interacts with actin, indicating that CAP2 has the capacity to bind to actin
  • has the capacity to bind to actin
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell polarity
    PATHWAY
    metabolism
    signaling signal transduction
    cAMP pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to adenyl cyclase binding, CAP, actin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS