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FLASH GENE

Symbol

CAP2

contributors: mct - updated : 03-05-2017

HGNC name	CAP, adenylate cyclase-associated protein, 2 (yeast)
HGNC id	20039

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	164.29 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CAP2 13 - 3080 52.7 477 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Nervous brain         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining epidermis     Homo sapiens Muscular striatum skeletal     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C-terminal fragment of CAP2 interacts with actin, indicating that CAP2 has the capacity to bind to actin

HOMOLOGY

interspecies	homolog to murine Cap2
	ortholog to rattus Cap2
	ortholog to murine 2810452G09Rik
	homolog to Drosophila capt
	homolog to C.elegans F41G4.2a

intraspecies

homolog to CAP1

Homologene

FAMILY

CAP family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	found in the nucleus in undifferentiated myoblasts and at the M-line of differentiated myotubes
	enriched in the nucleus, and sparse in the cytosol

basic FUNCTION	involved in establishment and/or maintenance of cell polarity
	having a regulatory bifunctional role
	C-terminal fragment of CAP2 interacts with actin, indicating that CAP2 has the capacity to bind to actin
	has the capacity to bind to actin

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	cell polarity

PATHWAY

metabolism

signaling

signal transduction

cAMP pathway

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to adenyl cyclase binding, CAP, actin

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS