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FLASH GENE
Symbol TGOLN2 contributors: mct - updated : 13-12-2010
HGNC name trans-golgi network protein 2
HGNC id 15450
Location 2p11.2      Physical location : 85.545.146 - 85.555.374
Synonym name
  • trans-Golgi network protein (46, 48, 51kD isoforms)
  • TGN38 homolog
  • trans-Golgi network protein TGN51
  • Synonym symbol(s) TGN38, TGN46, TGN51, TTGN2, TGN48, MGC14722, BX640868
    DNA
    TYPE functioning gene
    STRUCTURE 10.23 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388965 2 similar to hepatitis C virus core-binding protein 6; cervical cancer oncogene 3 SUCLG1 2p11.2 succinate-CoA ligase, GDP-forming, alpha subunit FLJ37357 2p11.2 hypothetical protein FLJ37357 LOC200383 2p11.2 similar to Dynein heavy chain at 16F FLJ23529 2p11.2 hypothetical protein FLJ23529 LOC129293 2p11.2 hypothetical protein LOC129293 TMSB10 2p11.2 thymosin, beta 10 KCMF1 2p11.2 potassium channel modulatory factor 1 LOC391388 2 hypothetical gene supported by AJ238095; NM_014463 TCF7L1 2p11.2 transcription factor 7-like 1 (T-cell specific, HMG-box) LOC388966 2 similar to hypothetical protein FLJ20296 TGOLN2 2p11.2 trans-golgi network protein 2 LOC388967 2 LOC388967 LOC388968 2 similar to Phosphatidylethanolamine-binding protein (PEBP) (Prostatic binding protein) (HCNPpp) (Neuropolypeptide h3) (Raf kinase inhibitor protein) (RKIP) FLJ20296 2p11.2 hypothetical protein FLJ20296 FLJ21977 2p11.2 hypothetical protein FLJ21977 CAPG 2cen-q24 capping protein (actin filament), gelsolin-like LOC284948 2p11.2 similar to B-cell linker; B cell linker protein MAT2A 2p11.2 methionine adenosyltransferase II, alpha GGCX 2p12 gamma-glutamyl carboxylase VAMP8 2p11.2-p11.1 vesicle-associated membrane protein 8 (endobrevin) VAMP5 2p11.2 vesicle-associated membrane protein 5 (myobrevin) LOC51255 2p11.2 hypothetical protein LOC51255 FLJ90024 2p11.2 fasting-inducible integral membrane protein TM6P1 LOC388969 2 LOC388969 USP39 2p11.2 ubiquitin specific protease 39 SFTPB 2p12-p11.2 surfactant, pulmonary-associated protein B GNLY 2p12-q11 granulysin HATH6 SIAT9 2p11.2 sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase) POLR1A 2p11.2 polymerase (RNA) 1 polypeptide A, 194kDa FLJ20758 2p11.2 FLJ20758 protein IMMT 2p11.2 inner membrane protein, mitochondrial (mitofilin) MRPL35 2p11.2 mitochondrial ribosomal protein L35 FLJ13110 2p11.2 hypothetical protein FLJ13110
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 splicing 6345 45.9 437 widely expressed 1998 9422759
    having a tyrosine containig motif YQRL
    - splicing 2200 48 453 barely expressed in embryonic kidney and promyelocytic cells 1998 9422759
    having two tyrosine containing motifs
    - splicing 2300 51 480 more abundant in fetal lung and kidney 1998 9422759
    having three tyrosine containing motifs
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
     thyroid   highly
    Lymphoid/Immunethymus   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple tyrosine containing motif
  • a tyrosine containing motif YQRL
  • a cytosolic domain interacting with AP2 clathrin adaptor complexes via the tyrosine-containing motif (-SDYQRL-) to direct internalization from the plasma membrane
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , secretory , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus
    text
  • trans-Golgi
  • type I membrane protein
  • constitutively cycles between the trans-Golgi network (TGN) and plasma membrane
  • partially colocalizes with RAB13 at the TGN and transferrin receptors in recycling endosomes )
  • accumulated predominantly in early endosomes
  • delivered to the plasma membrane, apparently together with SERPINB2 in the same vesicles, which after fusion with the membranes released cargo
  • basic FUNCTION
  • involved in regulating membrane traffic to and from trans-Golgi network
  • involved in the trafficking of integrin beta 1
  • may have a unique function in shuttling between the cell surface and the trans-Golgi network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text Golgi-plasma membrane transport vesicle
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • brain-specific F-actin binding protein neurabin-I is a TGOLN2-binding protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    consistently up-regulated in suicide cases as compared to controls
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS