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FLASH GENE
Symbol TGOLN2 contributors: mct - updated : 13-12-2010
HGNC name trans-golgi network protein 2
HGNC id 15450
Location 2p11.2      Physical location : 85.545.146 - 85.555.374
Synonym name
  • trans-Golgi network protein (46, 48, 51kD isoforms)
  • TGN38 homolog
  • trans-Golgi network protein TGN51
  • Synonym symbol(s) TGN38, TGN46, TGN51, TTGN2, TGN48, MGC14722, BX640868
    DNA
    TYPE functioning gene
    STRUCTURE 10.23 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 splicing 6345 45.9 437 widely expressed 1998 9422759
    having a tyrosine containig motif YQRL
    - splicing 2200 48 453 barely expressed in embryonic kidney and promyelocytic cells 1998 9422759
    having two tyrosine containing motifs
    - splicing 2300 51 480 more abundant in fetal lung and kidney 1998 9422759
    having three tyrosine containing motifs
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
     thyroid   highly
    Lymphoid/Immunethymus   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple tyrosine containing motif
  • a tyrosine containing motif YQRL
  • a cytosolic domain interacting with AP2 clathrin adaptor complexes via the tyrosine-containing motif (-SDYQRL-) to direct internalization from the plasma membrane
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , secretory , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus
    text
  • trans-Golgi
  • type I membrane protein
  • constitutively cycles between the trans-Golgi network (TGN) and plasma membrane
  • partially colocalizes with RAB13 at the TGN and transferrin receptors in recycling endosomes )
  • accumulated predominantly in early endosomes
  • delivered to the plasma membrane, apparently together with SERPINB2 in the same vesicles, which after fusion with the membranes released cargo
  • basic FUNCTION
  • involved in regulating membrane traffic to and from trans-Golgi network
  • involved in the trafficking of integrin beta 1
  • may have a unique function in shuttling between the cell surface and the trans-Golgi network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text Golgi-plasma membrane transport vesicle
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • brain-specific F-actin binding protein neurabin-I is a TGOLN2-binding protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    consistently up-regulated in suicide cases as compared to controls
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS